
CARS – Tutorials, Workshops and Special Events
09:00 NIH / NCI / CARS / EMA Special Session on Imaging as a Biomarker for Therapy Response
Wednesday, June 25, 2008; Room Kursaal
Session Chairs:
Laurence P. Clarke, PhD (USA), Keyvan Farahani, PhD (USA)
Imaging as a biomarker of therapy response is becoming an increasingly important field of research within the era of personalized medicine. Many sources of uncertainty exist in imaging as a biomarker. Biological variability, for example, is a factor both drug- and patient-dependent and thus difficult to characterize or model. However, other physical uncertainties associated with the image data collection and analysis platforms using an array of anatomical, functional or molecular imaging methods can be modeled or characterized. The creation of reference standards for quantitative imaging and image guided intervention, however, needs to be addressed as an international effort with all stake holders engaged from academic, industry and funding agencies. This session will thus address a review of the status of imaging as a biomarker in the clinical setting, current and planned initiatives by NIH and agencies of the US government to promote related imaging standards, and a review of EU related initiatives in this area. The presentations will be followed by a panel session that will explore how to encourage international collaboration for imaging standards for biomarkers for measurement of therapy response and image guided interventions. In addition, the panel session will address how to develop more standardized methods for data integration for a range of biomarkers in addition to imaging, namely genomics and proteomics.
The aim in this special CARS session is to present and discuss IT tools including data bases, architectures, and standards to assist in managing and representing genomics and proteomics data. Within the CARS R&D community there is considerable interest in how the “omics” can contribute to develop a modeling framework for patient data. The overarching goal of this activity is to specify a patient specific model which may assist in a personalized computer aided diagnosis and computer assisted therapy.
09:00 Predictive diagnosis and personalized treatment: dream or reality?
O. Golubnitschaja, MD, Univ. of Bonn (D)
9:15 Political, economical and social aspects of predictive medicine
V. Costigliola, Medicis Center, Brussels (B)
09:30 Current status and barriers for clinical implementation
M.W. Vannier, University of Chicago Medical Center (USA)
09:45 NIH Initiatives - current and planned, need for international standards
L. Clarke, PhD, NIH/NCI, Rockville (USA)
10:00 DICOM support for therapy imaging
H.U. Lemke, PhD, CARS Organization (D)
10:15 Panel discussion on the need for international standards for imaging as a biomarker for therapy response and response to image guided therapy
10:45 Break
